Collaboration on Alzheimer’s Disease Research

Collaboration on Alzheimer’s Disease Research (CADRE)

Dr. Pericak-Vance is a principal investigator of the National Institute on Aging funded Collaboration on Alzheimer Disease Research (CADRE), part of the congressionally mandated Alzheimer’s Disease Sequencing Project (ADSP)
CADRE aims to analyze whole genome sequence data generated during the Follow-Up Study phase of the National Institutes of Health Alzheimer’s Disease Program, incorporating large cohorts of patients and healthy individuals of diverse population groups. The Follow-Up Study phase will generate over 15,000 additional whole genome sequences on samples that encompass the richest possible ethnic diversity, including primarily Hispanic and African-American individuals. The CADRE project will provide the intensive and comprehensive analytical effort to uncover the wealth of information in these dataset of case-control cohorts and family study designs. Genomic analyses of the combined ADSP data will be performed to identify the highest priority variants and loci as candidates for functional analyses and testing as therapeutic targets.

CADRE is led at the University of Miami School of Medicine by Drs. Margaret A. Pericak-Vance, and Eden Martin, as joint principal investigators, supported by Dr. Gary Beecham. Principal investigators at the other Universities include Dr. Haines at Case Western Reserve University and Dr. Farrer from Boston University