Consortium for Alzheimer’s Disease Sequencing Analysis

Consortium for Alzheimer’s Disease Sequencing Analysis

Dr. Margaret A. Pericak-Vance, Director of the John P. Hussman Institute for Human Genomics (HIHG), is a principal investigator of the Nationa Institute on Aging funded Consortium for Alzheimer’s Sequence Analysis (CASA), part of the congressionally mandated Alzheimer’s Disease Sequencing Project (ADSP) as a collaboration between five universities.

CASA aims to analyze whole exome and whole genome sequence data generated during the first phase of the National Institutes of Health Alzheimer’s Disease Sequencing Program. Data will be analyzed from 6,000 volunteers with Alzheimer’s Disease (AD) and 5,000 cognitively intact individuals. In addition, genomic data from 111 large families with multiple AD members will be studied, including those of Caribbean Hispanic descent to identify rare genetic variants.

CASA is led at the University of Miami Miller School of Medicine by Drs. Margaret A. Pericak-Vance, Eden Martin-Director of the HIHG’s Center for Genetic Epidemiology and Statistical Genetics at the HIHG, and Gary Beecham, Director of the Division of Research Informatics in the Center for Genetic Epidemiology and Statistical Genetics at the HIHG. Principal Investigators from the four other Universities include Drs. Lindsay Farrer from Boston University Schools of Medicine and Public Health, Jonathan Haines from Case Western University School of Medicine, Richard Mayeux from Columbia University and Gerard Schellenberg from the Perelman School of Medicine at the University of Pennsylvania.