Publications

Top Publications in AD

Below is a curated list of the HIHG’s top publications on Alzheimer Disease from recent years. For a full list of our AD publications, please follow this link.

Beecham GW, Vardarajan B, Blue E, Bush W, Jaworski J . . . Pericak-Vance MA, Alzheimer’s Disease Sequencing Project. (2018). Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease. Neurol Genet.

Rajabli F, Feliciano BE, Celis K, Hamilton-Nelson KL, Whitehead PL, Adams LD, Bussies PL . . . Pericak-Vance MA (2018). Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS Genet.

Vardarajan BN, Barral S, Jaworski J, Beecham GW . . . Pericak-Vance MA, Mayeux R; Alzheimer’s Disease Sequencing Project, Wang LS. (2018). Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer’s disease. Ann Clin Transl Neurol.

Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G . . . Pericak-Vance MA, Schellenberg G, Jun GR, Farrer LA. (2018). Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease. Alzheimers Res Ther.

Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K… Di Narzo AF. (2017). Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers. Acta Neuropathol.

Jun, G. R., Chung, J., Mez, J., Barber, R., Beecham, G. W., Bennett, D. A., … & Cruchaga, C. (2017). Transethnic genome-wide scan identifies novel Alzheimer’s disease loci. Alzheimer’s & Dementia.

Mez, J., Chung, J., Jun, G., Kriegel, J., Bourlas, A. P., Sherva, R., … & Byrd, G. S. (2016). Two novel loci, COBL and SLC10A2, for Alzheimer’s disease in African Americans. Alzheimer’s & Dementia.

Haddick, P. C., Larson, J. L., Rathore, N., Bhangale, T. R., Phung, Q. T., Srinivasan, K., … & Farrer, L. A. (2017). A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer’s Disease Brains. Journal of Alzheimer’s Disease, (Preprint), 1-18.

Cuccaro, M. L., Carney, R. M., Zhang, Y., Bohm, C., Kunkle, B. W., Vardarajan, B. N., … & Pericak-Vance, M. A. (2016). SORL1 mutations in early-and late-onset Alzheimer disease. Neurology Genetics, 2(6), e116.

Cukier, H. N., Kunkle, B. W., Vardarajan, B. N., Rolati, S., Hamilton-Nelson, K. L., Kohli, M. A., … & Dykxhoorn, D. M. (2016). ABCA7 frameshift deletion associated with Alzheimer disease in African Americans. Neurology Genetics, 2(3), e79.

Ridge, P. G., Hoyt, K. B., Boehme, K., Mukherjee, S., Crane, P. K., Haines, J. L., … & Kauwe, J. S. (2016). Assessment of the genetic variance of late-onset Alzheimer’s disease. Neurobiology of aging, 41, 200-e13.

Hohman, T. J., Cooke-Bailey, J. N., Reitz, C., Jun, G., Naj, A., Beecham, G. W., … & Rajbhandary, R. (2016). Global and local ancestry in African-Americans: Implications for Alzheimer’s disease risk. Alzheimer’s & Dementia, 12(3), 233-243.

Hohman, T. J., Bush, W. S., Jiang, L., Brown-Gentry, K. D., Torstenson, E. S., Dudek, S. M., … & Martin, E. R. (2016). Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiology of aging, 38, 141-150.

Kohli, M. A., Cukier, H. N., Hamilton-Nelson, K. L., Rolati, S., Kunkle, B. W., Whitehead, P. L., … & Haines, J. L. (2016). Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease. Neurology Genetics, 2(1), e41.

Kunkle, B. W., Jaworski, J., Barral, S., Vardarajan, B., Beecham, G. W., Martin, E. R., … & DeStefano, A. L. (2016). Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer’s disease. Alzheimer’s & Dementia, 12(1), 2-10.

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J. C., Chung, J., Naj, A. C., … & Harold, D. (2016). A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular psychiatry, 21(1), 108-117.

Barral, S., Cheng, R., Reitz, C., Vardarajan, B., Lee, J., Kunkle, B., … & Haines, J. L. (2015). Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer’s disease. Alzheimer’s & Dementia, 11(12), 1397-1406.

Desikan, R. S., Schork, A. J., Wang, Y., Witoelar, A., Sharma, M., McEvoy, L. K., … & Harold, D. (2015). Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus. Molecular psychiatry, 20(12), 1588-1595.

Ghani, M., Reitz, C., Cheng, R., Vardarajan, B. N., Jun, G., Sato, C., … & Lin, C. F. (2015). Association of long runs of homozygosity with Alzheimer disease among African American individuals. JAMA neurology, 72(11), 1313-1323.

Humphries, C., Kohli, M. A., Whitehead, P., Mash, D. C., Pericak-Vance, M. A., & Gilbert, J. (2015). Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci. Molecular and Cellular Neuroscience, 67, 37-45.

Desikan, R. S., Schork, A. J., Wang, Y., Thompson, W. K., Dehghan, A., Ridker, P. M., … & Karow, D. S. (2015). Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Clinical Perspective. Circulation, 131(23), 2061-2069.

D’Aoust, L. N., Cummings, A. C., Laux, R., Fuzzell, D., Caywood, L., Reinhart-Mercer, L., … & Haines, J. L. (2015). Examination of candidate exonic variants for association to Alzheimer disease in the Amish. PloS one, 10(2), e0118043.

Wang, L. S., Naj, A. C., Graham, R. R., Crane, P. K., Kunkle, B. W., Cruchaga, C., … & Blennow, K. (2015). Rarity of the Alzheimer Disease–Protective APP A673T Variant in the United States. JAMA neurology, 72(2), 209-216.

Humphries, C. E., Kohli, M. A., Nathanson, L., Whitehead, P., Beecham, G., Martin, E., … & Gilbert, J. (2015). Integrated whole transcriptome and DNA methylation analysis identifies gene networks specific to late-onset Alzheimer’s disease. Journal of Alzheimer’s Disease, 44(3), 977-987.