Alzheimer’s Disease Sequencing Project

Alzheimer’s Disease Sequencing Project

The John P. Hussman Institute for Human Genomics (HIHG) is part of the congressionally mandated Alzheimer’s Disease Sequencing Project (ADSP), along with seven other university collaborators which include the University of Pennsylvania, Case Western Reserve University, Columbia University, Boston University, University of Washington, Washington University in St. Louis, and the University of Texas.

The goals of the ADSP are to identify new genomic variants contributing to increased risk of developing late-onset Alzheimer’s disease (LOAD) and protection against developing AD; to better understand why individuals with known risk factor variants do not develop AD; and to examine these factors in multi-ethnic populations in order to identify new pathways for disease prevention.

Since 2010, Dr. Pericak-Vance has co-led the analysis teams for the Alzheimer’s Disease Genetics Consortium, part of the ADSP. In addition, Dr. Pericak-Vance is also a principal investigator of the Consortium for Alzheimer’s Sequence Analysis funded by the National Institute on Aging, as part of the ADSP. The HIHG is also involved in multiple projects focusing on diverse populations, with the goal of addressing health disparities in genomic medical research.