Faculty : Derek Dykxhoorn, Ph.D

Derek Dykxhoorn, Ph.D.

Research Associate Professor, Dr. John T. Macdonald Foundation Department of Human Genetics
Co-Director, Center for Molecular Genetics, John P. Hussman Institute for Human Genomics
Associate Professor, Microbiology and Immunology

Derek M. Dykxhoorn, Ph.D., is an Associate Professor (Research) in the Dr. John T. Macdonald Foundation Department of Human Genetics, and the Department of Microbiology and Immunology. He serves as Director of the Center for Human Molecular Genetics at the John P. Hussman Institute for Human Genomics (HIHG). In addition, Dr. Dykxhoorn is Director of the HIHG induced pluripotent stem cell (iPSC) core facility which serves as a campus-wide resource for the derivation and implementation of iPSC-based technologies in disease modeling and therapeutic development, including the use of gene perturbation and genome editing strategies to understand the role that specific genes and genetic variants play in disease development. His current research focuses on understanding the impact that genetic and epigenetic variations have on the development of various disorders, such as, neurological disorders (Autism spectrum disorder, epilepsy, Alzheimer’s disease, and sensorineural disorders), cardiovascular disease (Long Qt syndrome), and viral infections. These experiments combine a variety of molecular biological, genomic, and electrophysiological approaches to examine the underlying molecular mechanisms that drive disease pathogenesis. Among our current studies in autism and epilepsy, we are using iPSCs to generate different populations of cells from the central nervous system – excitatory and inhibitory neurons, as well as 3D organoids – to examine how alterations in the balance between excitatory and inhibitory signals drives the development of these disorders. Our current studies in Alzheimer’s disease are focused on using iPSC-based technologies to understand how ethnic-specific genetic variants contribute to Alzheimer development by converging on pathways associated with endocytic trafficking and amyloid protein processing.

MyNCBI Link:

https://www.ncbi.nlm.nih.gov/sites/myncbi/1Zs77ht-Vt755/bibliography/50927182/public/?sort=date&direction=ascending

Top publications:

DeRosa BA, El Hokayem J, Artimovich E, Garcia-Serje C, Phillips AW, Van Booven D, Nestor JE, Wang L, Cuccaro ML, Vance JM, Pericak-Vance MA, Cukier HN, Nestor MW, Dykxhoorn DM. Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons. Sci Rep. 2018 May 30;8(1):8423.

DeRosa BA, Van Baaren JM, Dubey GK, Lee JM, Cuccaro ML, Vance JM, Pericak-Vance MA, Dykxhoorn DM. Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells. Neurosci Lett. 2012 May 10;516(1):9-14.

Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun;121(6):2401-12.

Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science. 2008 Feb 15;319(5865):921-6.

Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J. Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5953-8.