Faculty : Eden R. Martin, Ph.D.

Eden R. Martin, Ph.D.

Professor, Dr. John T. Macdonald Foundation Department of Human Genetics and Department of Public Health Sciences
Director, The Center for Genetic Epidemiology and Statistical Genetics, John P. Hussman Institute for Human Genomics

I am a statistical geneticist with experience in both theoretical methods development and applied research. My methodological work has focused on statistical methods for mapping complex diseases genes. This includes the development of early family-based tests for association and gene-gene interaction, as well as more recent methods for analysis of DNA sequence data. I have a particular interest in understanding how best to study genetic diseases in diverse, admixed groups, such as Hispanics. This has been a theme in both my theoretical investigations and applied work. In addition to my methodological work, I work on several applied genetic studies including studies of Parkinson disease, autism, chronic pain and Alzheimers disease. Presently, much of my research effort is devoted to understanding the genetics of Alzheimers disease as a leader in the Alzheimers Disease Sequencing Project (ADSP), and through my own projects focused on sex-specific effects and age of disease onset. I am more broadly interested in how genetics shape human traits in general, and over the past few years have led a study of the genetics of male sexual orientation, which has more recently expanded to female sexual orientation. These important studies provide insight on the biologic underpinnings of sexual orientation and related traits.

MyNCBI Link:

http://www.ncbi.nlm.nih.gov/sites/myncbi/eden.martin.1/bibliography/41167941/public/?sort=date&direction=ascending

Top publications:

  • Zhang L, Silva TC, Young JI, Gomez L, Schmidt MA, Hamilton-Nelson KL, Kunkle BW, Chen X, Martin ER, Wang L. Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease. Nat Commun. 2020 Nov 30;11(1):6114. doi: 10.1038/s41467-020-19791-w. PMID: 33257653; PMCID: PMC7704686.
  • Martin ER, Gao XR, Li YJ. An exploration of genetic association tests for disease risk and age at onset. Genet Epidemiol. 2020 Oct 19. doi: 10.1002/gepi.22368. Epub ahead of print. PMID: 33075194.
  • Naj AC, Lin H, Vardarajan BN, White S, Lancour D, Ma Y, Schmidt M, Sun F, Butkiewicz M, Bush WS, Kunkle BW, Malamon J, Amin N, Choi SH, Hamilton-Nelson KL, van der Lee SJ, Gupta N, Koboldt DC, Saad M, Wang B, Nato AQ, Sohi HK, Kuzma A, Wang LS, Adrienne Cupples L, van Duijn C, Seshadri S, Schellenberg GD, Boerwinkle E, Bis JC, Dupuis J, Salerno WJ, Wijsman EM, Martin ER*, DeStefano AL*. Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer’s disease sequencing project. Genomics. 2018 May 29. pii: S0888-7543(18)30281-7. doi: 10.1016/j.ygeno.2018.05.004. PMID: 29857119. *co-senior
  • Sanders AR, Beecham GW, Guo S, Dawood K, Rieger G, Badner JA, Gershon ES, Krishnappa RS, Kolundzija AB, Duan J; MGS Collaboration, Gejman PV, Bailey JM, Martin ER. Genome-Wide Association Study of Male Sexual Orientation. Sci Rep. 2017 Dec 7;7(1):16950. doi: 10.1038/s41598-017-15736-4. PMID: 29217827; PMCID: PMC5721098.
  • Moreno-Estrada A, Williams S, Gravel S, Zakharia F, McCauley JL, Byrnes JK, Gignoux CR, Ortiz-Tello P, Martinez RJ, Hedges DJ, Morris RW, Eng C, Sandoval K, Acevedo S, Martinez-Cruzado JC, Norman PJ, Layrisse Z, Parham P, Gonzalez-Burchard E, Cuccaro ML, Martin ER, Bustamante CD. Reconstructing the Population Genetic History of the Caribbean. PLOS Genet, 2013 Nov; 9(11):e1003925. doi: 10.1371/journal.pgen.1003925. PMCID: PMC3828151.