Faculty : Holly Cukier, Ph.D.

Holly Cukier, Ph.D.

Associate Director, Induced Pluripotent Stem Cell Core, John P. Hussman Institute for Human Genomics
Research Assistant Professor, Departments of Neurology and Human Genetics

Dr. Cukier graduated with a Bachelor’s in Science from the University of Miami in 1999 and earned her Doctoral degree in 2007 from Baylor College of Medicine in the Department of Human and Molecular Genetics where she generated a novel fruit fly model of Rett syndrome, a disorder on the autism spectrum. Dr. Cukier then returned to the University of Miami Miller School of Medicine and currently studies the genetics underlying Alzheimer’s disease and autism spectrum disorders. Dr. Cukier studies families with these diseases, as well as examining minority populations for identifying potential genetic differences. Furthermore, she is engaged in generating patient specific induced pluripotent stem cell lines to study and model the course of disease pathogenesis.

MyNCBI Link:

https://www.ncbi.nlm.nih.gov/sites/myncbi/1Zs77ht-Vt755/bibliography/50927182/public/?sort=date&direction=ascending

Top Publications:

  • Cukier HN, Kunkle BW, Vardarajan BN, Rolati S, Hamilton-Nelson KL, Kohli MA, Whitehead PL, Dombroski BA, Van Booven D, Lang R, Dykxhoorn DM, Farrer LA, Cuccaro ML, Vance JM, Gilbert JR, Beecham GW, Martin ER, Carney RM, Mayeux R, Schellenberg GD, Byrd GS, Haines JL, Pericak-Vance MA. ABCA7 frameshift deletion associated with Alzheimer disease in African Americans. Neurol Genet. 2016 Jun;2(3):e79. doi: 10.1212/NXG.0000000000000079. eCollection 2016 Jun. PubMed PMID: 27231719; PubMed Central PMCID: PMC4871806.
  • DeRosa BA, El Hokayem J, Artimovich E, Garcia-Serje C, Phillips AW, Van Booven D, Nestor JE, Wang L, Cuccaro ML, Vance JM, Pericak-Vance MA, Cukier HN, Nestor MW, Dykxhoorn DM. Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons. Sci Rep. 2018 May 30;8(1):8423. doi: 10.1038/s41598-018-26495-1. PubMed PMID: 29849033; PubMed Central PMCID: PMC5976773.
  • Cukier HN, Dueker ND, Slifer SH, Lee JM, Whitehead PL, Lalanne E, Leyva N, Konidari I, Gentry RC, Hulme WF, Booven DV, Mayo V, Hofmann NK, Schmidt MA, Martin ER, Haines JL, Cuccaro ML, Gilbert JR, Pericak-Vance MA. Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders. Mol Autism. 2014 Jan 10;5(1):1. doi: 10.1186/2040-2392-5-1. PubMed PMID: 24410847; PubMed Central PMCID: PMC3896704.
  • DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM. hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells. Mol Cell Neurosci. 2015 Sep;68:244-57. doi: 10.1016/j.mcn.2015.08.007. Epub 2015 Aug 16. PubMed PMID: 26284979; PubMed Central PMCID: PMC4593758.
  • Cukier HN, Perez AM, Collins AL, Zhou Z, Zoghbi HY, Botas J. Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet. 2008 Sep 5;4(9):e1000179. doi: 10.1371/journal.pgen.1000179. PubMed PMID: 18773074; PubMed Central PMCID: PMC2518867.