Faculty : Jacob L. McCauley, Ph.D

Jacob L. McCauley, Ph.D

Associate Professor, Dr. John T. Macdonald Foundation Department of Human Genetics and Department of Pathology
Director, Center for Genome Technology, John P. Hussman Institute for Human Genomics
Director, Biorepository Core Facility in the Center for Genome Technology, John P. Hussman Institute for Human Genomics

Jacob L. McCauley, Ph.D., is an Associate Professor of Human Genetics and Pathology at the University of Miami Miller School of Medicine within the Dr. John T. Macdonald Foundation Department of Human Genetics. He is also the Director of the Center for Genome Technology & Biorepository Facility at the John P. Hussman Institute for Human Genomics. Dr. McCauley is a genetic epidemiologist whose primary interest is to improve the understanding of human disease through disease gene discovery, genomics, and in-depth examination of environmental factors that influence disease outcome. His research focuses on the use of molecular techniques, bioinformatics, and statistical methods to identify genetic variation and to characterize its role in disease susceptibility within a variety of complex human diseases including multiple sclerosis, inflammatory bowel disease (IBD), stroke, and amyotrophic lateral sclerosis (ALS). In addition to leading his own NIH-funded research projects focused on the genetic aspects of both multiple sclerosis and inflammatory bowel disease within the US Hispanic population, Dr. McCauley contributes to a number of other large collaborative research efforts both nationally and internationally.

MyNCBI Link:

https://www.ncbi.nlm.nih.gov/myncbi/jacob.mccauley.1/bibliography/public/

Top Publications:

  • Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019 Sep 27;365(6460). doi: 10.1126/science.aav7188. PubMed PMID: 31604244; PubMed Central PMCID: PMC7241648.
  • Amezcua L, Beecham AH, Delgado SR, Chinea A, Burnett M, Manrique CP, Gomez R, Comabella M, Montalban X, Ortega M, Tornes L, Lund BT, Islam T, Conti D, Oksenberg JR, McCauley JL. Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis. Ann Clin Transl Neurol. 2018 Nov;5(11):1362-1371. doi: 10.1002/acn3.646. eCollection 2018 Nov. PubMed PMID: 30480030; PubMed Central PMCID: PMC6243381.
  • Damas OM, Gomez L, Quintero MA, Rampersaud E, Slifer S, Beecham GW, Kerman DH, Deshpande AR, Sussman DA, Abreu MT, McCauley JL. Genetic Characterization and Influence on Inflammatory Bowel Disease Expression in a Diverse Hispanic South Florida Cohort. Clin Transl Gastroenterol. 2017 Apr 13;8(4):e87. doi: 10.1038/ctg.2017.13. PubMed PMID: 28406493; PubMed Central PMCID: PMC5415895.
  • Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D’Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Nov;45(11):1353-60. doi: 10.1038/ng.2770. Epub 2013 Sep 29. PubMed PMID: 24076602; PubMed Central PMCID: PMC3832895.
  • Benatar M, Zhang L, Wang L, Granit V, Statland J, Barohn R, Swenson A, Ravits J, Jackson C, Burns TM, Trivedi J, Pioro EP, Caress J, Katz J, McCauley JL, Rademakers R, Malaspina A, Ostrow LW, Wuu J. Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS. Neurology. 2020 Jul 7;95(1):e59-e69. doi: 10.1212/WNL.0000000000009559. Epub 2020 May 8. PubMed PMID: 32385188; PubMed Central PMCID: PMC7371380.