Faculty : Jeffery M. Vance, M.D., Ph.D.

Jeffery M. Vance, M.D., Ph.D.

Professor and Founding Chair (2008-2013), Dr. John T. Macdonald Foundation Department of Human Genetics
Professor of Neurology
Director, Center for Genomic Education & Outreach, John P. Hussman Institute for Human Genomics

Jeffery M. Vance, M.D., Ph.D. is a Professor in the Dr. John T. Macdonald Foundation Department Human Genetics (founding Chairman, 2008-2012) and a Professor of Neurology at the University of Miami, Miller School of Medicine. He is boarded by both the American Board of Psychiatry and Neurology and the American College of Medical Genetics. His research has focused on the application of clinical, molecular, and mathematical genetic techniques to identify genes leading to human disease. He has collaborated on research in many different clinical specialties, but primary focus is on neurodegenerative disorders (Parkinson and Alzheimer disease) and Charcot-Marie-Tooth disease, as well as Autism. His current laboratory research focuses on identifying the protective variant(s) that lowers the risk for Alzheimer disease (AD) in African American ApoE4 carriers relative to European and Asian carriers of the ApoE4 allele. This work utilizes molecular and inducible pluripotent stem cell techniques, along with autopsy material. As a member of the Alzheimer Disease Sequencing Project (ADSP), he is also involved in the ADSP-Follow-up studies (ADSP-FUS) seeking to increase diversity in Alzheimer disease research. He is a recipient of a prestigious Zenith Award from the Alzheimer’s Association. He is also active in the education of students and is capstone director of the Genomic Medicine Master degree program for medical students and Principle investigator for the JJ Vance summer internship program at the HIHG. He receives funding from NIH (NIA, NINDS), The BrightFocus Foundation, the Alzheimer Association and the Hussman Foundation for Autism.

MyNCBI Link:

https://www.ncbi.nlm.nih.gov/myncbi/jeffery.vance.2/bibliography/public/

Top Publications:

  • Griswold AJ, Celis K, Bussies P, Rajabli F, Whitehead P, Hamilton-Nelson K, Beecham GW, Dykxhoorn DM, Nuytemans K, Wang L, Gardner OG, Dorfsman D, Bigio EH, Mesulam M, Weintraub S, Geula C, Gearing M, Martinez-McGrath E, Dalgard CL, Scott WK, Haines JL, Pericak-Vance MA, Young JI, Vance JM. “Increased APOEε4 expression is associated with the difference in Alzheimer Disease risk from diverse ancestral backgrounds.” Alzheimers Dement. 2020, in press.
  • Young JI, Sivasankaran SK, Wang L, Ali A, Mehta A, Davis DA, Dykxhoorn DM, Petito CK, Beecham GW, Martin ER, Mash DC, Pericak-Vance M, Scott WK, Montine TJ, Vance JM. “Genome-wide Brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease.” Neurol Genet. 2019 August;5(4):e342. PMID: 31403079.
  • Beecham GW, Dickson DW, Scott WK, Martin E R, Schellenberg G, on behalf of the Alzheimer Disease Genetics Consortium, Nuytemans K, Vance JM. “The PARK 10 locus is a major locus for sporadic, neuropathologically-confirmed Parkinson disease.” Neurology. 2015 Mar 10;84(10):972-80. PMID: 25663231.
  • Winn MP, Conlon PJ, Lynn KL, Farrington MK, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM (Corresponding Author), Rosenberg PB. “A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.” Science. 2005 Jun 17;308(5729):1801-4. PMID: 15879175
  • Züchner S, Mersiyanov IV, Muglia M, Bissar-Tadmouri N, Rochelle J, Nelis E, Dadali EL, Zappia M, Patitucci A, Parman Y, Jsenderek J, De Jonghe P, Pericak-Vance MA, Quattrone A, Battologlu E, Polyakov AV, Timmerman V, Schröder JM, Vance JM. “Mutations in the mitochondrial GTPase Mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A.” Nature Genetics. 2004 May;36(5): 449-51. PMID: 15064763