Faculty : Juan Young, Ph.D.

Juan Young, Ph.D.

Associate Research Professor, Dr. John T. Macdonald Foundation Department of Human Genetics
Co-Director, Center for Molecular Genetics, John P. Hussman Institute for Human Genomics

Dr Juan Young is a Research Associate Professor with a long-standing interest in genetic diseases and in epigenetic mechanisms of gene regulation. Thus, our laboratory has extensive experience in the investigation of epigenetic mechanisms underlying physiological and pathological processes. We use molecular techniques to understand the mechanisms underlying genetic disorders such as Rett Syndrome, Bohring-Opitz syndrome, GAND, Alzheimer disease and Clef lip and palate as well neuroprotection against cerebral ischemia. The lab has been performing in vivo work in mouse models, as well as in vitro and ex vivo experimental work for a number of years and is currently very well versed in epigenetic methodologies.

MyNCBI Link:


Top Publications:

  • Young JI, Sivasankaran SK, Wang L, Ali A, Mehta A, Davis DA, Dykxhoorn DM, Petito CK, Beecham GW, Martin ER, Mash DC, Pericak-Vance M, Scott WK, Montine TJ, Vance JM. Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease. Neurol Genet. 2019 Aug;5(4):e342. doi: 10.1212/NXG.0000000000000342. eCollection 2019 Aug. PubMed PMID: 31403079; PubMed Central PMCID: PMC6659138.
  • Khoury N, Xu J, Stegelmann SD, Jackson CW, Koronowski KB, Dave KR, Young JI, Perez-Pinzon MA. Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency. Mol Neurobiol. 2019 Jun;56(6):4549-4565. doi: 10.1007/s12035-018-1380-6. Epub 2018 Oct 20. PubMed PMID: 30343466; PubMed Central PMCID: PMC6475499.
  • Itzhak Y, Ergui I, Young JI. Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Mol Psychiatry. 2015 Feb;20(2):232-9. doi: 10.1038/mp.2014.7. Epub 2014 Feb 18. PubMed PMID: 24535458.
  • Camarena V, Cao L, Abad C, Abrams A, Toledo Y, Araki K, Araki M, Walz K, Young JI. Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome. EMBO Mol Med. 2014 Aug;6(8):1003-15. doi: 10.15252/emmm.201404044. PubMed PMID: 25001218; PubMed Central PMCID: PMC4154129.
  • Alvarez-Saavedra M, Carrasco L, Sura-Trueba S, Demarchi Aiello V, Walz K, Neto JX, Young JI. Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development. Hum Mol Genet. 2010 Jun 1;19(11):2177-90. doi: 10.1093/hmg/ddq096. Epub 2010 Mar 4. PubMed PMID: 20203171.