Faculty : Liyong Wang, Ph.D.

Liyong Wang, Ph.D.

Research Associate Professor, Dr. John T. Macdonald Foundation Department of Human Genetics

Dr.Wang received her Ph.D. in an Interdisciplinary Program of Nutrition at Purdue University and received her post-doctoral training in the Center for Human Genetics at Duke University. She joined the Institute for Human Genomics and Department of Human Genetics at the University of Miami in 2007. Dr. Wang’s research interest is to understand the genetic basis for common, complex human diseases using ever evolving genomic technologies. She has mapped susceptibility loci for cardiovascular diseases and neurodegenerative diseases, using linkage analysis, genome-wide association studies, copy number variation analysis, and next-generation sequencing studies. Recently, her research focuses have shifted to understanding the functional impact of genetic variants identified in the previous genetic studies and identifying “missing heritability” in the previous genetic studies. These gaps of knowledge will be filled using cutting edge epigenomic and genomic technologies, such as CRISPR, Hi-C, ATAC-seq, RNA-seq, DNA-methylation, and iPSC-derived disease-relevant cells. Dr. Wang has over 60 peer-reviewed publications.

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Top Publications:

  • Dueker ND, Doliner B, Gardener H, Dong C, Beecham A, Della-Morte D, Sacco RL, MD, Blanton SH, LWang†, Rundek T† An Extreme Phenotype Approach Suggests Taste Transduction Pathway for Carotid Plaque in a Multi-Ethnic Cohort. Stroke, In Press, June 2020
  • Wang L, Wei JQ, Da Fonseca Ferreira A, Wang H, Zhang L, Zhang Q, Bellio M, Chu XM, Khan A, Jayaweera D, Hare J, Dong C. Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived from Mesenchymal Stromal Cells. Journal of the American College of Cardiology, In Press, August 2020
  • Wang L, Pare G, Rundek T. DNA methylation predicts stroke outcome better, The epigenetic clock is ticking. Neurology 89:758-759, 2017
  • Wang L, Hara K, Van Baaren JM, Price JC, Beecham GW, Gallins PJ, Whitehead PL, Wang G, Lu C, Slifer MA, Züchner S, Martin ER, Mash D, Haines JL, Pericak-Vance MA, Gilbert JR. Vitamin D receptor and Alzheimer’s disease: a genetic and functional study. Neurobiol Aging. Aug;33(8):1844.e1-9, 2012
  • Wang L, Hauser ER, Shah SH, Pericak-Vance M, Harris M, Nelson S, Crosslin D, Hale AB, Haynes C, Gregory SG, Kraus WE, Goldschmidt-Clermont PJ, Vance JM and the GENECARD investigators. Peak-wide mapping on chromosome 3q13 identifies the Kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet, Apr;80(4):650-63, 2007. PMCID: PMC1852708.