Faculty : William K. Scott, Ph.D.

William K. Scott, Ph.D.

Professor, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, and Department of
Public Health Sciences
Executive Director, UM Brain Endowment Bank
Member, John P. Hussman Institute for Human Genomics

William K. Scott, Ph.D. is Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics, and Professor of Neurology and Public Health Sciences at the University of Miami Miller School of Medicine. He is a core faculty member of the John P. Hussman Institute for Human Genomics and Executive Director of the UM Brain Endowment Bank, one of six NIH-supported centers in the NeuroBioBank network. He also serves as Director of the Scholarly Concentration component of the NextGenMD medical curriculum. Dr. Scott’s research focuses on the identification of gene and environment interactions that influence the risk of complex diseases. He is a principal investigator on a multi-center study of the genetic factors underlying progression of symptoms in age-related macular degeneration, and one of three principal investigators of an effort to identify genetic factors that protect from the development of age-related cognitive impairment in Midwestern U.S. Amish communities. Other research projects examine genetic and genomic factors underlying primary open-angle glaucoma, post-traumatic stress disorder, genetic susceptibility to tuberculosis, and staphylococcal sepsis.

MyNCBI Link:


Top Publications:

  • Scott WK, Medie FM, Ruffin F, Sharma-Kuinkel BK, Cyr DD, Guo S, Dykxhoorn DM, Skov RL, Bruun NE, Dahl A, Lerche CJ, Petersen A, Larsen AR, Lauridsen TK, Johansen HK, Ullum H, Sørensen E, Hassager C, Bundgaard H, Schønheyder HC, Torp-Pedersen C, Østergaard LB, Arpi M, Rosenvinge F, Erikstrup LT, Chehri M, Søgaard P, Andersen PS, Fowler VG Jr. Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia. PLoS Genet. 2018 Oct;14(10):e1007667. doi: 10.1371/journal.pgen.1007667. eCollection 2018 Oct. PubMed PMID: 30289878; PubMed Central PMCID: PMC6192642.
  • Persad PJ, Heid IM, Weeks DE, Baird PN, de Jong EK, Haines JL, Pericak-Vance MA, Scott WK. Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4027-4038. doi: 10.1167/iovs.17-21734. PubMed PMID: 28813576; PubMed Central PMCID: PMC5559178.
  • Wang L, Maldonado L, Beecham GW, Martin ER, Evatt ML, Ritchie JC, Haines JL, Zabetian CP, Payami H, Pericak-Vance MA, Vance JM, Scott WK. DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient. Neurol Genet. 2016 Jun;2(3):e72. doi: 10.1212/NXG.0000000000000072. eCollection 2016 Jun. PubMed PMID: 27123490; PubMed Central PMCID: PMC4830205.
  • Courtenay MD, Cade W, Schwartz SG, Kovach JL, Agarwal A, Wang G, Haines JL, Pericak-Vance MA, Scott WK. Set-based joint test of interaction between SNPs in the VEGF pathway and exogenous estrogen finds association with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014 Jul 11;. doi: 10.1167/iovs.14-14494. [Epub ahead of print] PubMed PMID: 25015356; PubMed Central PMCID: PMC4126792.
  • Edwards DR, Gilbert JR, Hicks JE, Myers JL, Jiang L, Cummings AC, Guo S, Gallins PJ, Konidari I, Caywood L, Reinhart-Mercer L, Fuzzell D, Knebusch C, Laux R, Jackson CE, Pericak-Vance MA, Haines JL, Scott WK. Linkage and association of successful aging to the 6q25 region in large Amish kindreds. Age (Dordr). 2013 Aug;35(4):1467-77. doi: 10.1007/s11357-012-9447-1. Epub 2012 Jul 7. PubMed PMID: 22773346; PubMed Central PMCID: PMC3705095.