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The beneficial role of physical activity in preventing and treating cardiovascular disease (CVD) is well established. Increased exercise leads to reduced inflammation, improved insulin sensitivity, lipid profile and endothelial function, as well as a reduction in body mass, all key features important in the development of coronary heart disease, hypertension, diabetes mellitus, and metabolic syndrome. However, despite the abundance of epidemiological and clinical studies supporting the positive effects of exercise on health-related fitness and CVD, the mechanisms that explain this protective relationship remain largely unclear. For example, some physically active individuals can become hypertensive whereas other individuals can continue to have normal blood pressure despite leading a sedentary lifestyle. The current body of research suggests that underlying genetics is a key component in determining such inter-individual differences in exercise response…Read more>>