About GEAR


The beneficial role of physical activity in preventing and treating cardiovascular disease (CVD) is well established. Increased exercise leads to reduced inflammation, improved insulin sensitivity, lipid profile and endothelial function, as well as a reduction in body mass, all key features important in the development of coronary heart disease, hypertension, diabetes mellitus, and metabolic syndrome. However, despite the abundance of epidemiological and clinical studies supporting the positive effects of exercise on health-related fitness and CVD, the mechanisms that explain this protective relationship remain largely unclear. For example, some physically active individuals can become hypertensive whereas other individuals can continue to have normal blood pressure despite leading a sedentary lifestyle. The current body of research suggests that underlying genetics is a key component in determining such inter-individual differences in exercise response.

The purpose of the GEAR study is to identify genetic biomarkers and environmental risk factors that are associated with variation in exercise response among participants who undergo a 12 week exercise protocol.

This study will be conducted by the Hussman Institute for Human Genomics (HIHG) in collaboration with University of Miami Medical Wellness Center. We are interested in defining a gene expression profile that differentiates individuals who demonstrate different levels of response in health related fitness (HRF), following an exercise protocol. We will also examine whether and to what extent the interaction of previously identified genetic variants and environmental risk factors influences the response to exercise and HRF. The results from this study will allow us to better understand the relationship between genetics and exercise physiology and enable the future design of more efficient personalized exercise prescriptions that target genetically unique groups of individuals. This research has the potential to impact clinical preventive care treatments in at-risk populations. All healthy individuals are eligible for this study.