Publications

Publications

Hussman, J. P., Beecham, A. H., Schmidt, M., Martin, E. R., McCauley, J. L., Vance, J. M., … & Pericak-Vance, M. A. (2016). GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis. Genes and immunity.

International Multiple Sclerosis Genetics Consortium. (2015). Class II HLA interactions modulate genetic risk for multiple sclerosis. Nature genetics.

Hadjixenofontos, A., Beecham, A. H., Manrique, C. P., Pericak-Vance, M. A., Tornes, L., Ortega, M., … & Delgado, S. R. (2015). Clinical expression of multiple sclerosis in Hispanic whites of primarily Caribbean ancestry.Neuroepidemiology, 44(4), 262-268.

Bailey, J. N. C., Pericak-Vance, M. A., & Haines, J. L. (2014). The impact of the human genome project on complex disease. Genes, 5(3), 518-535.

International Multiple Sclerosis Genetics Consortium. (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature genetics, 45(11), 1353-1360.

Zuvich, R. L., Bush, W. S., McCauley, J. L., Beecham, A. H., De Jager, P. L., Ivinson, A. J., … & Pericak-Vance, M. A. (2011). Interrogating the complex role of chromosome 16p13. 13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complex.Human molecular genetics, 20(17), 3517-3524.

International Multiple Sclerosis Genetics Consortium, & Wellcome Trust Case Control Consortium 2. (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, 476(7359), 214-219.

Ban, M., McCauley, J. L., Zuvich, R., Baker, A., Bergamaschi, L., Cox, M., … & Dudbridge, F. (2010). A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.Genes and immunity, 11(8), 660-664.

Briggs, F. B., Bartlett, S. E., Goldstein, B. A., Wang, J., McCauley, J. L., Zuvich, R. L., … & Hafler, D. A. (2010). Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individuals. Human molecular genetics, 19(21), 4286-4295.

Briggs, F. B., Goldstein, B. A., McCauley, J. L., Zuvich, R. L., De Jager, P. L., Rioux, J. D., … & Oksenberg, J. R. (2010). Variation within DNA repair pathway genes and risk of multiple sclerosis. American journal of epidemiology, 172(2), 217-224.

Cree, B. A., Rioux, J. D., McCauley, J. L., Gourraud, P. A. F., Goyette, P., McElroy, J., … & Mirel, D. (2010). A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1* 15: 01. PLoS One, 5(6), e11296.

Bronson, P. G., Caillier, S., Ramsay, P. P., McCauley, J. L., Zuvich, R. L., De Jager, P. L., … & Sawcer, S. J. (2010). CIITA variation in the presence of HLA-DRB1* 1501 increases risk for multiple sclerosis. Human molecular genetics, 19(11), 2331-2340.

International Multiple Sclerosis Genetics Consortium. (2010). Lack of support for association between the KIF1B rs10492972 © variant and multiple sclerosis. Nature genetics, 42(6), 469-470.

International Multiple Sclerosis Genetics Consortium. (2010). Evidence for polygenic susceptibility to multiple sclerosis—the shape of things to come.The American Journal of Human Genetics, 86(4), 621-625.

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., De Jager, P. L., Aubin, C., … & Hafler, D. A. (2010). Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Human genetics, 127(5), 525-535.

Zuvich, R. L., McCauley, J. L., Pericak-Vance, M. A., & Haines, J. L. (2009, December). Genetics and pathogenesis of multiple sclerosis. In Seminars in immunology (Vol. 21, No. 6, pp. 328-333). Academic Press.

McCauley, J. L., Zuvich, R. L., Bradford, Y., Kenealy, S. J., Schnetz-Boutaud, N., Gregory, S. G., … & Haines, J. L. (2009). Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. Genes and immunity, 10(7), 624-630.

De Jager, P. L., Jia, X., Wang, J., De Bakker, P. I., Ottoboni, L., Aggarwal, N. T., … & Briskin, R. (2009). Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature genetics, 41(7), 776-782.

De Jager, P. L., Baecher-Allan, C., Maier, L. M., Arthur, A. T., Ottoboni, L., Barcellos, L., … & Yelensky, R. (2009). The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences,106(13), 5264-5269.

Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., … & Lincoln, R. (2007). Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis. Nature genetics, 39(9), 1083-1091.

International Multiple Sclerosis Genetics Consortium. (2007). Risk alleles for multiple sclerosis identified by a genomewide study. N engl J med,2007(357), 851-862.

McCauley, J. L., Kenealy, S. J., Margulies, E. H., Schnetz-Boutaud, N., Gregory, S. G., Hauser, S. L., … & Mortlock, D. P. (2007). SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. BMC genomics, 8(1), 266.

Yeo, T. W., De Jager, P. L., Gregory, S. G., Barcellos, L. F., Walton, A., Goris, A., … & Walsh, E. (2007). A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals of neurology, 61(3), 228-236.

Motsinger, A. A., Brassat, D., Caillier, S. J., Erlich, H. A., Walker, K., Steiner, L. L., … & Hauser, S. L. (2007). Complex gene–gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics, 8(1), 11-20.

Barcellos, L. F., Kamdar, B. B., Ramsay, P. P., DeLoa, C., Lincoln, R. R., Caillier, S., … & Hauser, S. L. (2006). Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. The Lancet Neurology, 5(11), 924-931.

Barcellos, L. F., Sawcer, S., Ramsay, P. P., Baranzini, S. E., Thomson, G., Briggs, F., … & Uccelli, A. (2006). Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Human molecular genetics, 15(18), 2813-2824.

Schmidt, S., Pericak-Vance, M. A., Sawcer, S., Barcellos, L. F., Hart, J., Sims, J., … & Oksenberg, J. R. (2006). Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. Genes and immunity, 7(5), 384-392.

Brassat, D., Motsinger, A. A., Caillier, S. J., Erlich, H. A., Walker, K., Steiner, L. L., … & Gregory, S. (2006). Multifactor dimensionality reduction reveals gene–gene interactions associated with multiple sclerosis susceptibility in African Americans. Genes and immunity, 7(4), 310-315.

Burwick, R. M., Ramsay, P. P., Haines, J. L., Hauser, S. L., Oksenberg, J. R., Pericak-Vance, M. A., … & Savettieri, G. (2006). APOE epsilon variation in multiple sclerosis susceptibility and disease severity Some answers.Neurology, 66(9), 1373-1383.

Kenealy, S. J., Herrel, L. A., Bradford, Y., Schnetz-Boutaud, N., Oksenberg, J. R., Hauser, S. L., … & Haines, J. L. (2006). Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes and immunity, 7(1), 73-76.

International Multiple Sclerosis Genetics Consortium. (2005). A high-density screen for linkage in multiple sclerosis. The American Journal of Human Genetics, 77(3), 454-467.

Kenealy, S. J., Babron, M. C., Bradford, Y., Schnetz-Boutaud, N., Haines, J. L., Rimmler, J. B., … & Oksenberg, J. R. (2004). A second-generation genomic screen for multiple sclerosis. The American Journal of Human Genetics, 75(6), 1070-1078.

Li, Y. J., Pericak-Vance, M. A., Haines, J. L., Siddique, N., McKenna-Yasek, D., Hung, W. Y., … & Saunders, A. M. (2004). Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis. Neurogenetics, 5(4), 209-213.

International Multiple Sclerosis Genetics Consortium. (2004). Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Human molecular genetics, 13(17), 1943-1949.

Barcellos, L. F., Begovich, A. B., Reynolds, R. L., Caillier, S. J., Brassat, D., Schmidt, S., … & Stillman, A. (2004). Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. Annals of neurology, 55(6), 793-800.

Pericak-Vance, M. A., Rimmler, J. B., Haines, J. L., Garcia, M. E., Oksenberg, J. R., Barcellos, L. F., … & Lyon-Caen, O. (2004). Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. Neurogenetics, 5(1), 45-48.

Oksenberg, J. R., Barcellos, L. F., Cree, B. A., Baranzini, S. E., Bugawan, T. L., Khan, O., … & Goodin, D. (2004). Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. The American Journal of Human Genetics, 74(1), 160-167.

Kenealy, S. J., Pericak-Vance, M. A., & Haines, J. L. (2003). The genetic epidemiology of multiple sclerosis. Journal of neuroimmunology, 143(1), 7-12.

Barcellos, L. F., Oksenberg, J. R., Begovich, A. B., Martin, E. R., Schmidt, S., Vittinghoff, E., … & Swerdlin, A. (2003). HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. The American Journal of Human Genetics, 72(3), 710-716.

Haines, J. L., Bradford, Y., Garcia, M. E., Reed, A. D., Neumeister, E., Pericak-Vance, M. A., … & Barcellos, L. F. (2002). Multiple susceptibility loci for multiple sclerosis. Human molecular genetics, 11(19), 2251-2256.

Schmidt, S., Barcellos, L. F., DeSombre, K., Rimmler, J. B., Lincoln, R. R., Bucher, P., … & Oksenberg, J. R. (2002). Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. The American Journal of Human Genetics, 70(3), 708-717.

Barcellos, L. F., Oksenberg, J. R., Green, A. J., Bucher, P., Rimmler, J. B., Schmidt, S., … & Hauser, S. L. (2002). Genetic basis for clinical expression in multiple sclerosis. Brain, 125(1), 150-158.

Pericak-Vance, M. A., Rimmler, J. B., Martin, E. R., Haines, J. L., Garcia, M. E., Oksenberg, J. R., … & Hauser, S. L. (2001). Linkage and association analysis of chromosome 19q13 in multiple sclerosis. Neurogenetics, 3(4), 195-201.

Green, A. J., Barcellos, L. F., Rimmler, J. B., Garcia, M. E., Caillier, S., Lincoln, R. R., … & Oksenberg, J. R. (2001). Sequence variation in the transforming growth factor-β1 (TGFB1) gene and multiple sclerosis susceptibility. Journal of neuroimmunology, 116(1), 116-124.

Barcellos, L. F., Schito, A. M., Rimmler, J. B., Vittinghoff, E., Shih, A., Lincoln, R., … & Pericak-Vance, M. A. (2000). CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis.Immunogenetics, 51(4-5), 281-288.

Fontaine, B., Cournu, I., Arnaud, I., Babron, M. C., Eichenbaum-Voline, S., Oksenberg, J. R., … & Lyon-Caen, O. (1999). Chromosome 17q22–q24 and multiple sclerosis genetic susceptibility. Genes & Immunity, 1(2).

Seboun, E., Oksenberg, J. R., Rombos, A., Usuku, K., Goodkin, D. E., Lincoln, R. R., … & Fitoussi, R. (1999). Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics, 2(3), 155-162.

Haines, J.L., Pericak-Vance, M.A. (1999). Genetics of multiple sclerosis. Curr Dir Autoimmun, 1:273-88.

Haines, J. L., Terwedow, H. A., Burgess, K., Pericak-Vance, M. A., Rimmler, J. B., Martin, E. R., … & Gatto, N. (1998). Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Human molecular genetics, 7(8), 1229-1234.

Haines, J. L., Ter-Minassian, M., Bazyk, A., Gusella, J. F., Kim, D. J., Terwedow, H., … & Lee, A. (1996). A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex.Nature genetics, 13(4), 469-471.