Our Studies : Lewy Body Dementia Research (LBD)

Lewy Body Dementia (LBD)

Approximately 5% of all dementia patients present with Dementia with Lewy Bodies (DLB), affecting a total of 2% of the general population above 65 years of age. Additionally, approximately 30% of Parkinson disease (PD) patients present with dementia symptoms more than one year later after PD diagnosis (PD with dementia, PDD). Together these phenotypes are called Lewy Body Dementias (LBD), and are often referred to as AD related dementia as they show overlap with both Alzheimer disease (AD) and PD on a clinical, pathological and genetic level.

Very limited information is known on underlying biological processes explaining these diseases. Genetic analyses in case-control cohorts and large families with a family history for disease have been instrumental in understanding biological processes for many other diseases. So far, however, genetic research in LBD has been very limited and mostly focused on analyses in non-Hispanic white cohorts.

The HIHG team led by Drs. Nuytemans, Pericak-Vance and Vance are committed to extend the LBD research beyond the overlap with AD and PD and into diverse populations to identify novel variants and understand genetic contributions to LBD across populations.

For more information, or to participate in our Lewy Body dementia study, please contact us at:
Phone: 1-877-686-6444
Email: LBD-HIHG@miami.edu